CQ1 User Meeting - Talks
by Réka Enz
As we had already mentioned, the first virtual CQ1 user meeting was a great success! We are now happy to share with you the contents of this meeting and present to you some great talks on research done on the CQ1 Confocal Imaging Cytometer. Thanks again to all the great minds who have contributed to his event and let us have a small insight into their work.
Dr. Lisa Sevenich (Georg-Speyer-Haus, Frankfurt, Germany)
The new insights into tumor-stroma interactions in brain metastasis by confocal microscopy and 3D reconstruction
The brain represents a unique tissue environment with highly specialised brain-specific cells, including astrocytes and microglia, which perform important physiological functions such as maintaining the blood-brain barrier and immune surveillance. Tumour cell invasion disrupts cellular homeostasis and leads to accumulation of brain-specific cells in metastatic lesions and recruitment of immune and inflammatory cells from the periphery. It is known that paracrine circuits between tumour cells and tumour-associated stromal cells critically influence disease progression and response to therapy. However, our understanding of how brain metastatic cells from different primary tumours (melanoma, breast and lung cancer) activate and use stromal cells to support the rate-limiting steps of brain metastasis is currently limited. In this talk, Dr Lisa Sevenich describes new findings in the field of tumour-stroma interaction in brain metastases. She uses the Yokogawa CQ1 confocal microscope to microscope the 3D structures of the brain at high speed. This microscope also allows the microscopy of time-dependent, dynamic cell processes in which, for example, the microglia cells are observed in their movements and localisations.
If you are interested in the other talks, please find the videos here:
Prof. Dr. Yohei Yamauchi (ETH Zürich, Switzerland): Cell Biology of Virus infections
Özlem Yavas (InSphero AG, Zurich, Switzerland): Quantifying beta-cell proliferation in pancreatic islets by 3D colocalization analysis of confocal images
Lise Harbom (AxoSim, New Orleans, Louisiana, USA): In Vitro Drug Discovery Models NerveSim® and BrainSim®
PD Dr. Claudia Stäubert (University Leipzig, Germany): HCA3 and GPR84 – two metabolite-sensing GPCRs with opposing functions in innate immune cells
MD PhD Stefan Florian (Charité Berlin, Germany): High-resolution multiplex immunofluorescence confocal imaging in breast cancer biomarker discovery